Master's Research Project
Format: 3-5 minute 3D animation (720p)
* Expected Completion Date: July 2015 | This is currently a work in progress.
Committee Members: Prof. Nick Woolridge (BMC supervisor) | Dr. Tania Watts (content expert, UofT immunology department)
Audience: Undergraduate immunology students | The general public
Software: Autodesk Maya | Pixologic Zbrush | Autodesk Mudbox | Adobe After Effects | Adobe Audition | Adobe Photoshop | Adobe Illustrator
Funding: University of Toronto Immunology Department
Project Concept: Influenza is a highly contagious and severe viral infection that causes high mortality rates within the human population year after year. Immunization is an effective means of preventing the spread of influenza, yet to this day there is a lack of awareness both within the public and among healthcare professionals regarding the safety of vaccination, as well as the severity of the disease. This project will provide a complete three dimensional overview of the molecular mechanisms of viral entry and infection, as well as contrast the immune response of a vaccinated and an unvaccinated individual. We expect that the final video will provide students with the foundation and understanding to undertake further research in this field of immunology and to take correct measures for disease prevention in their future jobs.
Concept Environment Sketches | Colour Scripts
Medium: Adobe Photoshop CS6 | Wacom Intuos 3
Storyboard
Medium: Adobe Photoshop CS6 | Wacom Intuos 3
References
Braciale, T., et al. (2012). Regulating the adaptive immune response to respiratory virus infection. Nature Reviews Immunology, 295-305.
Doherty, P., et al. (2006). Influenza and the challenge for immunology. Nature Immunology, 7(5), 449-455.
Fineberg, H. (2014). Pandemic Preparedness and Response — Lessons from the H1N1 Influenza of 2009. New England Journal of Medicine, 370(14), 1335-1342.
Huang, K. A. et al. (2014). Virus-Specific Antibody Secreting Cell, Memory B-cell, and Sero-Antibody Responses in the Human Influenza Challenge Model. Journal of Infectious Diseases, 1354-1361.
Kim, T., et al. (2011). T cell responses during influenza infection: Getting and keeping control. Trends in Immunology, 32(5), 225-231.
Kreijtz, J., et al. (2011). Immune Responses To Influenza Virus Infection. Virus Research, 162, 19-30.
Palese, P. (2004). Influenza: Old and new threats. Nature Medicine, 10(12), S82-S87.
Sun, J., & Braciale, T. (2013). Role of T cell immunity in recovery from influenza virus infection. Current Opinion in Virology, 425-429.
Zhang, Y., et al. (2002). Apoptosis and reduced influenza A virus specific CD8 T cells in aging mice. Cell Death and Differentiation, 651-660.
